Hydroxychloroquine, marketed under the trade name Plaquenil, is primarily an antimalarial medicine. It is also a member of the 4-Aminoquinoline drug class. While antimalarial medicines are a type of naturally produced anti-parasitic used to prevent malaria, 4-aminoquinoline are antimalarial pharmaceuticals used in the treatment of erythrocytic plasmodial diseases such as malaria. Hydroxychloroquine's effectiveness for Covid is currently being researched.
What is Hydroxychloroquine used for?
It is used to treat active malaria as well as a malaria prophylactic drug before traveling to a malaria zone. It is also utilized as a therapy strategy for discoid and systemic lupus erythematosus (inflammatory conditions of the skin). It is also used as an effective DMARD (Disease-modifying Anti-Rheumatic Drug) in instances of rheumatoid arthritis and post-Lyme arthritis that have not responded to previous therapies. Hydroxychloroquine is occasionally used to treat Porphyria Cutanea Tarda, a skin disease with liver damage. It is also used in some cases of Sjogren's Syndrome, an autoimmune illness that causes extreme dryness. Hydroxychloroquine has just been discovered to be beneficial in treating Adult Covid-19 sufferers, but study into this is still ongoing.
Dosage of Hydroxychloroquine
Hydroxychloroquine 200mg has an effect on the function of lysosomes in both humans and the malaria parasite. Lysosomes are cell organelles that contain digesting enzymes and are membrane-bound. They are employed to kill invading germs in the human body by breaking down worn-out cell components. The capacity of the parasites to proteolyze hemoglobin is impacted by changing their pH, which inhibits their development and reproduction. The buildup of hydroxychloroquine in human cell organelles elevates their pH and aids in the cell's inflammatory response, which aids in the management of Lupus symptoms. It also suppresses inflammation in rheumatoid arthritis by inhibiting TLR-9 receptors and activating the innate immune system.
Hydroxychloroquine is available in 200mg and 400mg tablet dosages. They come in white to off-white film-coated tablets with Plaquenil inscribed on them. The pills are available in bottles of 60 or 100 tablets. The prophylactic dosage of this drug for malaria is 400mg once weekly for adults and children patients weighing more than 31kg. The dose for severe malaria is 800mg every 6 hours, 24 hours, and 48 hours. It is not advised for children under the age of 31, and the prophylactic dosage should be given two weeks before traveling to the malarial belt. The dosages of Hydroxychloroquine for Rheumatoid Arthritis range from 400mg to 600mg, while those for Systemic Lupus Erythematosus and Chronic Discoid Lupus Erythematosus range from 200mg to 400mg, depending on the severity of the illness.
Some of the most frequent adverse effects of this drug are headache, nausea, and vomiting. These side effects are avoidable by drinking enough water while taking the medicine. However, the drug can also cause dizziness, sleepiness, blurred vision, and hearing loss. As a result, patients should avoid driving or using heavy machinery after taking the pill. The medication has the potential to interact with a few other medicines, resulting in significant adverse effects. Antacids should thus be given 4 hours before or after the medicine. Ampicillin should be taken around an hour before or after the medicine. Ampicillin should be taken around an hour before or after the medicine. In order to minimize problems, it is also critical to inform your doctor about any allergies you have to certain substances or drugs before beginning the prescription.